Antibacterial activity of the penicillins.

Antibacterial activity, penicillinase stability and inducing ability of different penicillins.

There are now a t least three main types of antibacterial activity shown by different penicillins-the ordinary penicillin G type, the type shown by methicillin active against penicillinase-producing staphylococci and the. ‘ broad spectrum ’ type of activity shown by a-aminobenzylpenicillin. The inducing capacity of different penicillins can be measured by the concentration required for maximal ...

Isolation of a Penicillin Acylase Producing E.coli and Kinetic Characterization of the Whole Cell Enzyme Activity

Penicillin acylase (EC 3.5.1.11) has been a target of study for a long time because of its pivotal role in the deacylation of the penicillin into the 6- aminopenicillanic acid (6-APA) and the side-chain organic acids. This property of penicillin acylase has been exploited commercially for large scale production of 6-APA, which is the key intermediate in the manufacture of semi-synthetic penicil...

Effect of pH upon the activity of cefoxitin.

Cefoxitin is a new semisynthetic cephamycin antibiotic, effective against gram-positive and gram-negative bacteria. It is of particular interest because of its activity against cephalosporinresistant strains of Escherichia coli, indole-positive Proteus, Klebsiella and Serratia6) and because of its high resistance to hydrolysis by /J-lactamases3). Antibacterial activities of penicillins and ceph...

Synthesis and antibacterial activity of triazole and isoxazole derivatives of ampicillin.

In order to improve the antibacterial activity of ampicillin, new penicillin derivatives having a 1-aryltriazole-4-carboxamide group or a 5-arylisoxazole-3-carboxamide group at the alpha-position of benzylpenicillin or p-hydroxybenzylpenicillin were synthesized. Some compounds in these series were found to possess high activity against Pseudomonas and other Gram-negative bacteria. In addition, ...

Synthesis and antibacterial activity of a novel biphenyl-ureido penicillin.

In vitro activity of ticarcillin, carbenicillin and ampicillin against some gram-negative bacilli.

alpha-Carboxy-3-thienylmethyl penicillin (ticarcillin) is a relatively new semisynthetic penicillin which is more active than carbenillin against Pseudomonas aeruginosa. Among the strains tested, those isolated from the respiratory tract showed an increased susceptibility to carbenicillin and ticarcillin. As with carbenicillin, synergistic activity against P. aeruginosa could be demonstrated wi...